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Dextran CLIO Magnetic Nanoparticles - Fluorescent Dye

Dextran CLIO Magnetic Nanoparticles - Fluorescent Dye

General Information

Fluorescent dye functionalized Dextran coated crosslinked iron oxide nanoparticles (CLIO-DYE) have 1-3 superparamagnetic Fe3O4 iron oxide cores (8-10 nm in diameter) imbedded within the matrix of dextran sugar strands of 40 kDa or 70 kDa size. Dextran strands are crosslinked to prevent their disassociation, ensuring long-term biological stability. Fluorophores are covalently conjugated to the nanoparticle surface.

 

Features

  • Highly magnetic
  • Highly biocompatible, non-toxic
  • Fluorescently labeled (AFDye 488, AFDye 555, AFDye 647, or IR750 dye)
  • Long term stable under physiological conditions
  • 40 kDa and 70 kDa dextran coats are available
  • Dual-modality magnetic and fluorescence probes

 

Applications

  • Dual-modality probes for MRI and Fluorescence imaging
  • In vitroand in vivolabels for cells and tissues
  • Dual magnetic and florescence cell separation

 

Specifications

  • Iron Oxide Core Diameter: 8 – 10 nm
  • Hydrodynamic Diameter: 60 – 80 nm
  • Polydispersity Index (PDI): < 0.25
  • Nanoparticle Charge: Between -3 and -0.3 mV
  • Magnetization:  5 – 30 emu/g (room temperature)
  • Fluorescent dye: AF488, Cy3, Cy5, or IR750
  • Shelf life: > 1 year (4°C storage)
  • Supplied as liquid suspension in water

 

Citations:

  1. Gu, Huan, et al. "Magnetically driven active topography for long-term biofilm control." Nature communications 11.1 (2020): 1-11.
C$505.96Price

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