Dextran CLIO Magnetic Nanoparticles - Fluorescent Dye

General Information
Fluorescent dye functionalized Dextran coated crosslinked iron oxide nanoparticles (CLIO-DYE) have 1-3 superparamagnetic Fe3O4 iron oxide cores (8-10 nm in diameter) imbedded within the matrix of dextran sugar strands of 40 kDa or 70 kDa size. Dextran strands are crosslinked to prevent their disassociation, ensuring long-term biological stability. Fluorophores are covalently conjugated to the nanoparticle surface.
 
Features
Highly magnetic
Highly biocompatible, non-toxic
Fluorescently labeled (AFDye 488, AFDye 555, AFDye 647, or IR750 dye)
Long term stable under physiological conditions
40 kDa and 70 kDa dextran coats are available
Dual-modality magnetic and fluorescence probes
 
Applications
Dual-modality probes for MRI and Fluorescence imaging
In vitroand in vivolabels for cells and tissues
Dual magnetic and florescence cell separation
 
Specifications
Iron Oxide Core Diameter: 8 – 10 nm
Hydrodynamic Diameter: 60 – 80 nm
Polydispersity Index (PDI): < 0.25
Nanoparticle Charge: Between -3 and -0.3 mV
Magnetization:  5 – 30 emu/g (room temperature)
Fluorescent dye: AF488, Cy3, Cy5, or IR750
Shelf life: > 1 year (4°C storage)
Supplied as liquid suspension in water
 
Citations:
Gu, Huan, et al. "Magnetically driven active topography for long-term biofilm control." Nature communications 11.1 (2020): 1-11.